The PANDORA programme is about understanding the socio-ecological drivers of emerging zoonosis and persistence of transboundary pathogens at human/environment/wildlife/domestic animal interfaces in contrasted landscapes as a means to trial novel veterinary, medical and preventive solutions. PANDORA is the core programme and other projects have arisen from this platform, including a Queen Mary’s led UKRI GCRF COVID Lockdown Project and an IDRC funded West-African One-Health Action for Mitigating Outbreaks project.