The RVC Oncobiome Bank aims to archive intestinal microbiome (faecal) samples from canine and feline cancer patients at the time of their diagnosis, to enable future oncobiome research.

Challenge       

In people, the intestinal microbiome has emerged as a key modulator of cancer biology, influencing tumor development, host immune function, treatment response, toxicity profiles, and overall patient outcomes. Alterations in microbial composition and function (dysbiosis) have been linked to carcinogenesis, modulation of systemic inflammation, and variability in response to chemotherapy, radiotherapy, and immunotherapy.

Solution      

In veterinary oncology, we are at a very early stage in characterising these relationships. We therefore aim to establish the RVC Oncobiome Bank, a biobank of faecal samples from dogs and cats at the time of their cancer diagnosis. We also aim to store matched residual plasma/serum samples from the time of diagnosis. The biobank will allow for long-term sample storage supporting future DNA, RNA and metabolomic oncobiome research projects. Establishing a faecal biobank for veterinary (canine and feline) oncology patients will enable important and foundational research into the impact of cancer on intestinal health (and vice versa), treatment-induced microbiome disruption, and the role of dysbiosis in modulating therapeutic efficacy and prognosis. A biobank will facilitate exploration of microbiome-associated biomarkers and support future interventional studies, including dietary modulation, pre- and probiotic supplementation, and faecal microbiota transplantation. Once the biobank has been established, it will enable larger-scale microbiome research without the need for lengthy prospective studies.

Impact      

Given the shared environment, disease biology, and treatment strategies between humans and companion animals, this area of work has strong translational relevance, with potential to inform both veterinary and human oncology. To our knowledge, this will be the first dedicated veterinary oncobiome bank in the UK/Europe.

Partners      

Funded by the RVC Animal Care Trust.