Dr. Andrew Mead

PhD MRes BSc(Hons) BA(Hons)
Lecturer in Antimicrobial Resistance

Department: Pathobiology & Population Sciences

Campus: Hawkshead

Research Groups: Antimicrobial Resistance

Andrew is a Lecturer in Antimicrobial Resistance at the RVC, specialising in antimicrobial pharmacology, PK/PD modelling, and experimental infection models to optimise antimicrobial use and understand resistance selection in veterinary pathogens.

Andrew graduated with a BSc (Hons) in Biomedical Science from the University of Bedfordshire, where he subsequently worked as a Senior Laboratory Technician. He later completed an MRes at the Royal Veterinary College (RVC), funded by the Veterinary Medicines Directorate (VMD), establishing the use of dynamic hollow fibre infection models (HFIM) to evaluate veterinary antimicrobial therapies.

Andrew obtained his PhD from the RVC in 2022, focusing on PK/PD-informed clinical breakpoint determination for colistin use in poultry to minimise resistance emergence and support One Health antimicrobial sustainability. This work was awarded the McKeever Prize for the best original research paper related to animal health.

He is currently a Lecturer in Antimicrobial Resistance at the RVC, where his research integrates microbiology, pharmacology, and pharmacometric modelling to optimise antimicrobial therapy and investigate resistance selection. He leads and supports experimental infection model research within the APPRAISE facility and collaborates extensively with academic, regulatory, and industry partners.

Andrew contributes to international antimicrobial susceptibility and pharmacology initiatives and is a member of VetCAST, ENOVAT, and the ESCMID PK/PD of Anti-Infectives Study Group (EPASG). He has contributed to international best-practice guidance on hollow fibre infection models endorsed by ESCMID.

Publications:

Alabdulkarim, N., Readman, J., Mead, A., Oakley, R., Wenker, S., …., Standing, J. (2026) Systematic review of antimicrobial pharmacokinetic/pharmacodynamic indices in murine thigh and hollow fibre infection models. Journal of Antimicrobial Chemotherapy 81(1), dkaf446. https://doi.org/10.1093/jac/dkaf446

Ruchti, N., Ferran, A. A., Mead, A., Pelligand, L., Viel, A., Boulanger, M., & Overesch, G. (2025). Minimum inhibitory concentrations of sulfonamides and trimethoprim for veterinary pathogens: new data for old antibiotics. Veterinary Microbiology, 110784. https://doi.org/10.1016/j.vetmic.2025.110784

Mead, A., and Pelligand, L. (2025) Time kill curve PD modelling experiments are affected by trailing MIC endpoints: refinement of MIC determination for S. pseudintermedius. Journal of Veterinary Pharmacology and Therapeutics https://doi.org/10.1111/jvp.70033

Mead, A., Azzariti, S, Hughes, A., Toutain, P.L., Pelligand, L. (2025) Florfenicol Sustained-Release formulation does not promote resistance emergence in non-target bacteria: hollow-fibre infection studies with pig pathogens and commensals. Journal of Applied Microbiology, 136(8), lxaf200. https://doi.org/10.1093/jambio/lxaf200

Hughes, A., Pelligand, L., Andersson, D.I., Mead, A. (2025) Selection for florfenicol resistance at sub-MIC concentrations in Pasteurella multocida. PLoS One 20(6): e0327115.https://doi.org/10.1371/journal.pone.0327115

Mead, A., Hughes, A., Azzariti, S., Toutain, PL., Pelligand, L. (2025) Phenotype-Specific Semi-Mechanistic Modelling of Florfenicol Time-Kill Curves in G. parasuis Compared to Other Respiratory Pathogens. Journal of Veterinary Pharmacology and Therapeutics (JVPT), https://doi.org/10.1111/jvp.13500

Mead, A., Azzariti, S. and Pelligand, L., (2024). Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms. Access Microbiology, pp.000744-v1. https://doi.org/10.1099/acmi.0.000744.v3

Rotchell, J.M., Austin, C., .... Mead, A., Filart, K., Beeby, E. and Cunningham, K., (2024). Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants. Ecotoxicology and Environmental Safety, 274, p.116208. https://doi.org/10.1016/j.ecoenv.2024.116208

Azzariti, S., Mead, A., Toutain, P. L., Bond, R., & Pelligand, L. (2023). Time-Kill Analysis of Canine Skin Pathogens: A Comparison of Pradofloxacin and Marbofloxacin. Antibiotics, 12(10), 1548. https://doi.org/10.3390/antibiotics12101548

Buick, E., Mead, A., Alhubaysh, A., ...., Renshaw, D. and Farnaud, S., (2023). CellShip: An Ambient Temperature Transport and Short-Term Storage Medium for Mammalian Cell Cultures. Biopreservation and Biobanking.  https://doi.org/10.1089/bio.2023.0100

Mead, A., Toutain, PL., Richez, P., & Pelligand, L. (2023) Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens. Nature Scientific Reports. (Journal Impact Factor: 4.996) https://doi.org/10.1038/s41598-023-39727-w

Mead, A., Toutain, PL., Richez, P., & Pelligand, L. (2022) Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves. Antimicrobial agents and chemotherapy.  https://doi.org/10.1128/aac.00793-22

Mead, A., Billon-Lotz, C., Olsen, R., Swift, B., Richez, P., Stabler, R., & Pelligand, L. (2022). Epidemiological Prevalence of Phenotypical Resistances and Mobilised Colistin Resistance in Avian Commensal and Pathogenic E. coli from Denmark, France, The Netherlands, and the UK. Antibiotics. https://doi.org/10.3390/antibiotics11050631

Mead, A., Gillard, N., Robert, C., Pierret, G., Henrottin, J., Richez, P., & Pelligand, L. (2021) Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of veterinary pharmacology and therapeutics. https://doi.org/10.1111/jvp.13022

Mead, A., Richez, P., Azzariti, S., & Pelligand, L. (2021). Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli. Frontiers in Veterinary Science, 8, 634. https://doi.org/10.3389/fvets.2021.698135

Sadouki, Z., McHugh, T. D., Aarnoutse, R., Ortiz Canseco, J., Darlow, C., Hope, W., Ingen, J., Longshaw, C., Manissero, D., Mead, A., ... & Kloprogge, F. (2021). Application of the hollow fibre infection model (HFIM) in antimicrobial development: a systematic review and recommendations of reporting. Journal of Antimicrobial Chemotherapy, 76(9), 2252-2259. https://doi.org/10.1093/jac/dkab160

Mead, A., Lees, P., Mitchell, J., Rycroft, A., Standing, J., Toutain, PL., & Pelligand, L. (2019) Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannhaemia haemolytica and Pasteurella multocida in three growth media. Journal of veterinary pharmacology and therapeutics, 42(1), pp. 52-59.  https://doi.org/10.1111/jvp.12719

Conference presentations

Mead, A. (2024) A comparative analysis of bacteriostatic activity: trimethoprim versus sulphonamides. Antimicrobial Agents in Veterinary Medicine (AAVM), Athens, Greece.

Mead, A. (2023) What are we targeting? Prediction of dose optimisation for treatment of heteroresistant enteric E. coli in broiler chicken using PK/PD integration. ECCMID, Copenhagen, Denmark.

Mead, A. (2022) Semi-mechanistic modelling of time-kill analysis highlights E. coli heteroresistance to colistin. Antimicrobial Agents in Veterinary Medicine (AAVM), Madrid, Spain.

Mead, A. and Pelligand, L. (2022) PK/PD informed breakpoint determination for colistin in chicken. London Pharmacometric interest group (LPIG), University College London.

Mead, A., Stabler, R., and Pelligand, L. (2021) PK/PD informed clinical breakpoint determination for colistin in chicken to limit emergence of resistance and improve One Health antimicrobial sustainability. Post-graduate research symposium, Royal Veterinary College.

Mead, A., Richez, P., Azzariti, S., and Pelligand, L. (2020) Evaluation of colistin dosing on enteric E. coli in poultry. Antimicrobial Agents in Veterinary Medicine (AAVM), Online.

Mead, A., and Pelligand, L. (2019) Dynamic in vitro modelling: curbing the antimicrobial crisis, iBEST and School of Life sciences seminar series, University of Bedfordshire.

Mead, A., Lees, P., Rycroft, A., Standing J., Mitchell, J. & Pelligand, L. (2018) Hollow-fibre PK/PD modelling of oxytetracycline against bovine Pasteurella multocida. – ECCMID Abstract and Poster

Mead, A., Stabler, R., and Pelligand, L. (2018) PK/PD informed clinical breakpoint determination for colistin in chicken to limit emergence of resistance and improve One Health antimicrobial sustainability. Post-graduate research symposium, Royal Veterinary College.

Mead, A., and Pelligand, L. (2018) Curbing the antimicrobial crisis through dynamic in vitro modelling. Biomedical Seminar Series, University of Hull.

Andrew contributes to undergraduate and postgraduate teaching across the Biosciences programmes at the RVC. He teaches bacteriology within the Principles of Infectious Disease and Control of Infectious Disease modules, delivering both lectures and practical laboratory sessions. He is also Module Lead for Advanced Concepts in Bio-Business.

Andrew supervises undergraduate, MSci, MRes, and PhD research projects, with a focus on experimental infection models, antimicrobial pharmacodynamics, and resistance selection. He is particularly interested in supporting students seeking research experience in antimicrobial pharmacology and One Health AMR.

Prospective students or visiting researchers interested in applying for external funding opportunities to work or study with Andrew at the RVC are encouraged to make contact to discuss potential projects and supervision.

Andrew is happy to be contacted regarding outreach activities / opportunities.

Andrew is an active member of the Researcher Association (RA) which represents research staff at all stages, from research assistants to fixed-term senior research fellows across the RVC, within the Research Concordat Working Group.

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